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AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau. Our laboratory has previously demonstrated that passive immunization with an anti-tau antibody, HJ8.5, decreased accumulation of pathological tau in a human P301S tau-expressing transgenic...
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| Опубликовано в: : | J Exp Med |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413341/ https://ncbi.nlm.nih.gov/pubmed/28416651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162125 |
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