AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

Tauopathies are characterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau. Our laboratory has previously demonstrated that passive immunization with an anti-tau antibody, HJ8.5, decreased accumulation of pathological tau in a human P301S tau-expressing transgenic...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Ising, Christina, Gallardo, Gilbert, Leyns, Cheryl E.G., Wong, Connie H., Jiang, Hong, Stewart, Floy, Koscal, Lauren J., Roh, Joseph, Robinson, Grace O., Remolina Serrano, Javier, Holtzman, David M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413341/
https://ncbi.nlm.nih.gov/pubmed/28416651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162125
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