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Directed evolution of human scFvs in DT40 cells
Cells that constitutively diversify their immunoglobulin genes can be used for selection of novel antibodies and for refining existing affinities and specificities. Here, we report an adaptation of the chicken DT40 system wherein its capacity for somatic hypermutation is harnessed to evolve human an...
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| 出版年: | Protein Eng Des Sel |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840456/ https://ncbi.nlm.nih.gov/pubmed/26519451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv058 |
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