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Directed evolution of human scFvs in DT40 cells
Cells that constitutively diversify their immunoglobulin genes can be used for selection of novel antibodies and for refining existing affinities and specificities. Here, we report an adaptation of the chicken DT40 system wherein its capacity for somatic hypermutation is harnessed to evolve human an...
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| Publicado en: | Protein Eng Des Sel |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840456/ https://ncbi.nlm.nih.gov/pubmed/26519451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv058 |
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