Targeting tauopathy with engineered tau-degrading intrabodies

BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tau...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Gallardo, Gilbert, Wong, Connie H., Ricardez, Sara M., Mann, Carolyn N., Lin, Kent H., Leyns, Cheryl E. G., Jiang, Hong, Holtzman, David M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805661/
https://ncbi.nlm.nih.gov/pubmed/31640765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0340-6
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