Targeting tauopathy with engineered tau-degrading intrabodies

BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tau...

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Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Gallardo, Gilbert, Wong, Connie H., Ricardez, Sara M., Mann, Carolyn N., Lin, Kent H., Leyns, Cheryl E. G., Jiang, Hong, Holtzman, David M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805661/
https://ncbi.nlm.nih.gov/pubmed/31640765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0340-6
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