NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

Inflammation in the brain accompanies several high-impact neurological diseases including multiple sclerosis (MS), stroke, and Alzheimer’s disease. Neuroinflammation is sterile, as damage-associated molecular patterns rather than microbial pathogens elicit the response. The inflammasome, which leads...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Freeman, Leslie, Guo, Haitao, David, Clément N., Brickey, W. June, Jha, Sushmita, Ting, Jenny P.-Y.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413320/
https://ncbi.nlm.nih.gov/pubmed/28404595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150237
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