The Nucleotide-binding Leucine-rich Repeat (NLR) Family Member NLRX1 Mediates Protection against Experimental Autoimmune Encephalomyelitis and Represses Macrophage/Microglia-induced Inflammation

The nucleotide binding domain and leucine-rich repeat-containing (NLR) family of proteins is known to activate innate immunity, and the inflammasome-associated NLRs are prime examples. In contrast, the concept that NLRs can inhibit innate immunity is still debated, and the impact of such inhibitory...

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Detalhes bibliográficos
Main Authors: Eitas, Timothy K., Chou, Wei-Chun, Wen, Haitao, Gris, Denis, Robbins, Gregory R., Brickey, June, Oyama, Yoshitaka, Ting, Jenny P.-Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924282/
https://ncbi.nlm.nih.gov/pubmed/24366868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533034
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