NLRC5-dependent activation of the inflammasome

The nucleotide-binding domain (NBD) leucine rich repeat (LRR) containing proteins, NLRs, are intracellular sensors of PAMPs and DAMPs. A subgroup of NLRs can form inflammasome complexes, which facilitate the maturation of pro-caspase-1 to caspase-1, leading to IL-1β and IL-18 cleavage and secretion....

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Autori principali: Davis, Beckley K., Roberts, Reid A., Huang, Max T., Willingham, Stephen B., Conti, Brian J., Brickey, W. June, Barker, Brianne R., Kwan, Mildred, Taxman, Debra J., Accavitti-Loper, Mary-Ann, Duncan, Joseph A., Ting, Jenny P-Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669680/
https://ncbi.nlm.nih.gov/pubmed/21191067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003111
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