The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer

Experimental, clinical, and epidemiological findings support the concept of developmental origins of health and disease (DOHAD), suggesting that early-life hormonal influences during a sensitive period around adolescence have a powerful impact on cancer morbidity later in life. The endocrine changes...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Podlutsky, Andrej, Valcarcel-Ares, Marta Noa, Yancey, Krysta, Podlutskaya, Viktorija, Nagykaldi, Eszter, Gautam, Tripti, Miller, Richard A., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411369/
https://ncbi.nlm.nih.gov/pubmed/28233247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-017-9966-x
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