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Pre-clinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers

PURPOSE: CD70 expression in normal tissues is restricted to activated lymphoid tissues. Targeting CD70 on CD70-expressing tumors could mediate “on-target, off-tumor” toxicity. This study was to evaluate the feasibility and safety of using anti-human CD70 CARs to treat cancer patients whose tumors ex...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Wang, Qiong J., Yu, Zhiya, Hanada, Ken-ichi, Patel, Krishna, Kleiner, David, Restifo, Nicholas P., Yang, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411349/
https://ncbi.nlm.nih.gov/pubmed/27803044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1421
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