MKP-1 Negatively Regulates LPS-mediated IL-1β Production Through p38 Activation and HIF-1α Expression

Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that plays a major role in inflammatory diseases as well as cancer. The inflammatory response after Toll-like receptor (TLR) 4 activation is tightly regulated through phosphorylation of MAP kinases, including p38 and JNK pathways. The activat...

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Bibliographic Details
Published in:Cell Signal
Main Authors: Talwar, Harvinder, Bauerfeld, Christian, Bouhamdan, Mohamad, Farshi, Pershang, Liu, Yusen, Samavati, Lobelia
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410178/
https://ncbi.nlm.nih.gov/pubmed/28238855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.02.018
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