High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells

Tyrosine kinase inhibitors (TKIs), despite efficacy as anti-cancer therapeutics, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We used patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healt...

詳細記述

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書誌詳細
出版年:Sci Transl Med
主要な著者: Sharma, Arun, Burridge, Paul W., McKeithan, Wesley L., Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C., del Álamo, Juan C., Wu, Sean M., Moslehi, Javid J., Mercola, Mark, Wu, Joseph C.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409837/
https://ncbi.nlm.nih.gov/pubmed/28202772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2584
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