Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro

Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving patient safety and preventing drug attrition. Human induced pluripotent stem cells (hiPSCs) enable the study of pharmacological and toxicological responses in patient-specific cardiomyocytes (CMs), and may ser...

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Publicado no:Cell Stem Cell
Main Authors: Matsa, Elena, Burridge, Paul W., Yu, Kun-Hsing, Ahrens, John H., Termglinchan, Vittavat, Wu, Haodi, Liu, Chun, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Shao, Ningyi, Woo, Nicole A., Chao, Alexander S., Gold, Joseph D., Karakikes, Ioannis, Snyder, Michael P., Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087997/
https://ncbi.nlm.nih.gov/pubmed/27545504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.07.006
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