Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

β-adrenergic signaling pathways mediate key aspects of cardiac function. Its dysregulation is associated with a range of cardiac diseases, including dilated cardiomyopathy (DCM). Previously, we established an iPSC model of familial DCM from patients with a mutation in TNNT2, a sarcomeric protein. He...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Stem Cell
Hlavní autoři: Wu, Haodi, Lee, Jaecheol, Vincent, Ludovic G., Wang, Qingtong, Gu, Mingxia, Lan, Feng, Churko, Jared, Sallam, Karim, Matsa, Elena, Sharma, Arun, Gold, Joseph D., Engler, Adam J., Xiang, Yang K., Bers, Donald M., Wu, Joseph C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546705/
https://ncbi.nlm.nih.gov/pubmed/26095046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.04.020
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky