Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

β-adrenergic signaling pathways mediate key aspects of cardiac function. Its dysregulation is associated with a range of cardiac diseases, including dilated cardiomyopathy (DCM). Previously, we established an iPSC model of familial DCM from patients with a mutation in TNNT2, a sarcomeric protein. He...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Wu, Haodi, Lee, Jaecheol, Vincent, Ludovic G., Wang, Qingtong, Gu, Mingxia, Lan, Feng, Churko, Jared, Sallam, Karim, Matsa, Elena, Sharma, Arun, Gold, Joseph D., Engler, Adam J., Xiang, Yang K., Bers, Donald M., Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546705/
https://ncbi.nlm.nih.gov/pubmed/26095046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.04.020
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