Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity

Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical market. Several chemotherapeutic compounds have been noted for their propensities to induce dangerous cardiac-specific side effects such as arrhythmias or cardiomyocyte apoptosis. However, improved preclinical...

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Udgivet i:Nat Protoc
Main Authors: Sharma, Arun, McKeithan, Wesley L., Serrano, Ricardo, Kitani, Tomoya, Burridge, Paul W., del Álamo, Juan C., Mercola, Mark, Wu, Joseph C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502639/
https://ncbi.nlm.nih.gov/pubmed/30413796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-018-0076-8
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