Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs

Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in development. For example, long QT syndrome‐3 (LQTS3) is caus...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Gomez‐Galeno, Jorge, Okolotowicz, Karl, Johnson, Mark, McKeithan, Wesley L., Mercola, Mark, Cashman, John R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322572/
https://ncbi.nlm.nih.gov/pubmed/34327875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.828
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