High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells

Tyrosine kinase inhibitors (TKIs), despite efficacy as anti-cancer therapeutics, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We used patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healt...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Sharma, Arun, Burridge, Paul W., McKeithan, Wesley L., Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C., del Álamo, Juan C., Wu, Sean M., Moslehi, Javid J., Mercola, Mark, Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409837/
https://ncbi.nlm.nih.gov/pubmed/28202772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2584
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