High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells

Tyrosine kinase inhibitors (TKIs), despite efficacy as anti-cancer therapeutics, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We used patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healt...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Sharma, Arun, Burridge, Paul W., McKeithan, Wesley L., Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C., del Álamo, Juan C., Wu, Sean M., Moslehi, Javid J., Mercola, Mark, Wu, Joseph C.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409837/
https://ncbi.nlm.nih.gov/pubmed/28202772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2584
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