High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells

Tyrosine kinase inhibitors (TKIs), despite efficacy as anti-cancer therapeutics, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We used patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healt...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Sharma, Arun, Burridge, Paul W., McKeithan, Wesley L., Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C., del Álamo, Juan C., Wu, Sean M., Moslehi, Javid J., Mercola, Mark, Wu, Joseph C.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409837/
https://ncbi.nlm.nih.gov/pubmed/28202772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2584
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