High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells

Tyrosine kinase inhibitors (TKIs), despite efficacy as anti-cancer therapeutics, are associated with cardiovascular side effects ranging from induced arrhythmias to heart failure. We used patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Transl Med
Prif Awduron: Sharma, Arun, Burridge, Paul W., McKeithan, Wesley L., Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M., Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C., del Álamo, Juan C., Wu, Sean M., Moslehi, Javid J., Mercola, Mark, Wu, Joseph C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409837/
https://ncbi.nlm.nih.gov/pubmed/28202772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2584
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