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Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia
The eleven-nineteen leukemia (ENL) protein family, composed of ENL and AF9, is a common component of 3 transcriptional modulators: AF4–ENL–P-TEFb complex (AEP), DOT1L-AF10-ENL complex (referred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1). Each complex associates with chromatin...
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| Publicado en: | J Clin Invest |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409830/ https://ncbi.nlm.nih.gov/pubmed/28394257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91406 |
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