MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters

Mixed-lineage leukemia (MLL) maintains the expression of cellular memory genes during development, while leukemic MLL fusion proteins aberrantly maintain expression of hematopoietic stem cell program genes such as HOXA9 to cause leukemia. However, the molecular mechanism of gene activation is unclea...

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Detalhes bibliográficos
Main Authors: Okuda, Hiroshi, Kawaguchi, Marie, Kanai, Akinori, Matsui, Hirotaka, Kawamura, Takeshi, Inaba, Toshiya, Kitabayashi, Issay, Yokoyama, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985622/
https://ncbi.nlm.nih.gov/pubmed/24465000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1394
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