HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

HOXA9 is often highly expressed in leukemias. However, its precise roles in leukemogenesis remain elusive. Here, we show that HOXA9 maintains gene expression for multiple anti-apoptotic pathways to promote leukemogenesis. In MLL fusion-mediated leukemia, MLL fusion directly activates the expression...

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Vydáno v:eLife
Hlavní autoři: Miyamoto, Ryo, Kanai, Akinori, Okuda, Hiroshi, Komata, Yosuke, Takahashi, Satoshi, Matsui, Hirotaka, Inaba, Toshiya, Yokoyama, Akihiko
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313233/
https://ncbi.nlm.nih.gov/pubmed/34310280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64148
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