Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia

The eleven-nineteen leukemia (ENL) protein family, composed of ENL and AF9, is a common component of 3 transcriptional modulators: AF4–ENL–P-TEFb complex (AEP), DOT1L-AF10-ENL complex (referred to as the DOT1L complex) and polycomb-repressive complex 1 (PRC1). Each complex associates with chromatin...

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Foilsithe in:J Clin Invest
Main Authors: Okuda, Hiroshi, Stanojevic, Boban, Kanai, Akinori, Kawamura, Takeshi, Takahashi, Satoshi, Matsui, Hirotaka, Takaori-Kondo, Akifumi, Yokoyama, Akihiko
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409830/
https://ncbi.nlm.nih.gov/pubmed/28394257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91406
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