Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages

Mycobacterium tuberculosis is known to modulate the host immune responses to facilitate its persistence inside the host cells. One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise mechanism of CIITA and M...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Sengupta, Srabasti, Naz, Saba, Das, Ishani, Ahad, Abdul, Padhi, Avinash, Naik, Sumanta Kumar, Ganguli, Geetanjali, Pattanaik, Kali Prasad, Raghav, Sunil Kumar, Nandicoori, Vinay Kumar, Sonawane, Avinash
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409457/
https://ncbi.nlm.nih.gov/pubmed/28209712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775205
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