Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages

Mycobacterium tuberculosis is known to modulate the host immune responses to facilitate its persistence inside the host cells. One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise mechanism of CIITA and M...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Sengupta, Srabasti, Naz, Saba, Das, Ishani, Ahad, Abdul, Padhi, Avinash, Naik, Sumanta Kumar, Ganguli, Geetanjali, Pattanaik, Kali Prasad, Raghav, Sunil Kumar, Nandicoori, Vinay Kumar, Sonawane, Avinash
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409457/
https://ncbi.nlm.nih.gov/pubmed/28209712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775205
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