Mouse Bone Marrow Sca-1(+) CD44(+) Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway

Mycobacterium tuberculosis primarily infects lung macrophages. However, a recent study showed that M. tuberculosis also infects and persists in a dormant form inside bone marrow mesenchymal stem cells (BM-MSCs) even after successful antibiotic therapy. However, the mechanism(s) by which M. tuberculo...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Naik, Sumanta Kumar, Padhi, Avinash, Ganguli, Geetanjali, Sengupta, Srabasti, Pati, Sanghamitra, Das, Dasarathi, Sonawane, Avinash
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607403/
https://ncbi.nlm.nih.gov/pubmed/28739828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00471-17
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