The subcellular localization of neuronal nitric oxide synthase determines the downstream effects of NO on myocardial function

AIMS: In healthy hearts, the neuronal nitric oxide synthase (nNOS) is predominantly localized to the sarcoplasmic reticulum (SR), where it regulates the ryanodine receptor Ca(2+ )release channel (RyR2) and phospholamban (PLB) phosphorylation, and to a lesser extent to the sarcolemmal membrane where...

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Publicado en:Cardiovasc Res
Autores principales: Carnicer, Ricardo, Suffredini, Silvia, Liu, Xing, Reilly, Svetlana, Simon, Jillian N., Surdo, Nicoletta C., Zhang, Yin H., Lygate, Craig A., Channon, Keith M., Casadei, Barbara
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408949/
https://ncbi.nlm.nih.gov/pubmed/28158509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx002
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