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Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

Atrial fibrillation (AF) is a growing public health burden, and its treatment remains a challenge. AF leads to electrical remodeling of the atria, which in turn promotes AF maintenance and resistance to treatment. Although remodeling has long been a therapeutic target in AF, its causes remain poorly...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Reilly, Svetlana N., Liu, Xing, Carnicer, Ricardo, Recalde, Alice, Muszkiewicz, Anna, Jayaram, Raja, Carena, Maria Cristina, Wijesurendra, Rohan, Stefanini, Matilde, Surdo, Nicoletta C., Lomas, Oliver, Ratnatunga, Chandana, Sayeed, Rana, Krasopoulos, George, Rajakumar, Timothy, Bueno-Orovio, Alfonso, Verheule, Sander, Fulga, Tudor A., Rodriguez, Blanca, Schotten, Ulrich, Casadei, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993239/
https://ncbi.nlm.nih.gov/pubmed/27225184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac4296
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