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The subcellular localization of neuronal nitric oxide synthase determines the downstream effects of NO on myocardial function
AIMS: In healthy hearts, the neuronal nitric oxide synthase (nNOS) is predominantly localized to the sarcoplasmic reticulum (SR), where it regulates the ryanodine receptor Ca(2+ )release channel (RyR2) and phospholamban (PLB) phosphorylation, and to a lesser extent to the sarcolemmal membrane where...
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Publicado no: | Cardiovasc Res |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5408949/ https://ncbi.nlm.nih.gov/pubmed/28158509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx002 |
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