Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling

BACKGROUND: Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure overload, and both are ameliorated by exogenous tetrahydrob...

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Опубликовано в: :J Am Heart Assoc
Главные авторы: Hashimoto, Toru, Sivakumaran, Vidhya, Carnicer, Ricardo, Zhu, Guangshuo, Hahn, Virginia S., Bedja, Djahida, Recalde, Alice, Duglan, Drew, Channon, Keith M., Casadei, Barbara, Kass, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943286/
https://ncbi.nlm.nih.gov/pubmed/27001967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003208
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