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Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling

BACKGROUND: Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure overload, and both are ameliorated by exogenous tetrahydrob...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Hashimoto, Toru, Sivakumaran, Vidhya, Carnicer, Ricardo, Zhu, Guangshuo, Hahn, Virginia S., Bedja, Djahida, Recalde, Alice, Duglan, Drew, Channon, Keith M., Casadei, Barbara, Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943286/
https://ncbi.nlm.nih.gov/pubmed/27001967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003208
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