Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

Endothelial nitric-oxide synthase (eNOS) is a critical regulator of vascular homeostasis by generation of NO that is dependent on the cofactor tetrahydrobiopterin (BH4). When BH4 availability is limiting, eNOS becomes “uncoupled,” resulting in superoxide production in place of NO. Recent evidence su...

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Autores principales: Crabtree, Mark J., Brixey, Rachel, Batchelor, Helen, Hale, Ashley B., Channon, Keith M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537053/
https://ncbi.nlm.nih.gov/pubmed/23139420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415992
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