Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

Tetrahydrobiopterin (BH4) is a required cofactor for the synthesis of NO by endothelial nitric oxide synthase (eNOS), and endothelial BH4 bioavailability is a critical factor in regulating the balance between NO and superoxide production (eNOS coupling). Biosynthesis of BH4 is determined by the acti...

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Autores principales: Crabtree, Mark J., Hale, Ashley B., Channon, Keith M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science 2011
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Original Contribution
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121954/
https://ncbi.nlm.nih.gov/pubmed/21402147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.03.010
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