A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast‐cycling stem cells. The number and identity of these dividing and migrating stem cells are maintained by a mosaic pattern at the base of the crypt. How the underlying regulatory scheme manages this dynamic stem...

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Veröffentlicht in:Mol Syst Biol
Hauptverfasser: Chen, Kai‐Yuan, Srinivasan, Tara, Tung, Kuei‐Ling, Belmonte, Julio M, Wang, Lihua, Murthy, Preetish Kadur Lakshminarasimha, Choi, Jiahn, Rakhilin, Nikolai, King, Sarah, Varanko, Anastasia Kristine, Witherspoon, Mavee, Nishimura, Nozomi, Glazier, James A, Lipkin, Steven M, Bu, Pengcheng, Shen, Xiling
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408779/
https://ncbi.nlm.nih.gov/pubmed/28455349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167324
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