A miR-34a-Numb feed-forward loop triggered by inflammation regulates asymmetric stem cell division in intestine and colon cancer

Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here we show that miR-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent fee...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Stem Cell
Autors principals: Bu, Pengcheng, Wang, Lihua, Chen, Kai-Yuan, Srinivasan, Tara, Murthy, Preetish Kadur Lakshminarasimha, Tung, Kuei-Ling, Varanko, Anastasia Kristine, Chen, Huanhuan Joyce, Ai, Yiwei, King, Sarah, Lipkin, Steven M., Shen, Xiling
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751059/
https://ncbi.nlm.nih.gov/pubmed/26849305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.01.006
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars