A miR-34a-Numb feed-forward loop triggered by inflammation regulates asymmetric stem cell division in intestine and colon cancer

Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here we show that miR-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent fee...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Bu, Pengcheng, Wang, Lihua, Chen, Kai-Yuan, Srinivasan, Tara, Murthy, Preetish Kadur Lakshminarasimha, Tung, Kuei-Ling, Varanko, Anastasia Kristine, Chen, Huanhuan Joyce, Ai, Yiwei, King, Sarah, Lipkin, Steven M., Shen, Xiling
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751059/
https://ncbi.nlm.nih.gov/pubmed/26849305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.01.006
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