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Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Despite the continuous renewal and turnover of the small intestinal epithelium, the intestinal crypt maintains a ‘soccer ball-like’, alternating pattern of stem and Paneth cells at the base of the crypt. To study the robustness of the alternating pattern, we used intravital two-photon microscopy in...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Choi, Jiahn, Rakhilin, Nikolai, Gadamsetty, Poornima, Joe, Daniel J., Tabrizian, Tahmineh, Lipkin, Steven M., Huffman, Derek M., Shen, Xiling, Nishimura, Nozomi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054609/
https://ncbi.nlm.nih.gov/pubmed/30030455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29230-y
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