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Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging

Despite the continuous renewal and turnover of the small intestinal epithelium, the intestinal crypt maintains a ‘soccer ball-like’, alternating pattern of stem and Paneth cells at the base of the crypt. To study the robustness of the alternating pattern, we used intravital two-photon microscopy in...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Choi, Jiahn, Rakhilin, Nikolai, Gadamsetty, Poornima, Joe, Daniel J., Tabrizian, Tahmineh, Lipkin, Steven M., Huffman, Derek M., Shen, Xiling, Nishimura, Nozomi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054609/
https://ncbi.nlm.nih.gov/pubmed/30030455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29230-y
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