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Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer
Current orthotopic xenograft models of human colorectal cancer (CRC) require surgery and do not robustly form metastases in the liver, the most common site clinically. CCR9 traffics lymphocytes to intestine and colorectum. We engineered use of the chemokine receptor CCR9 in CRC cell lines and patien...
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| Publicado en: | Nat Biotechnol |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532544/ https://ncbi.nlm.nih.gov/pubmed/26006007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3239 |
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