Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer

Current orthotopic xenograft models of human colorectal cancer (CRC) require surgery and do not robustly form metastases in the liver, the most common site clinically. CCR9 traffics lymphocytes to intestine and colorectum. We engineered use of the chemokine receptor CCR9 in CRC cell lines and patien...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Biotechnol
Main Authors: Chen, Huanhuan Joyce, Sun, Jian, Huang, Zhiliang, Hou, Harry, Arcilla, Myra, Rakhilin, Nikolai, Joe, Daniel J., Choi, Jiahn, Gadamsetty, Poornima, Milsom, Jeff, Nandakumar, Govind, Longman, Randy, Zhou, Xi Kathy, Edwards, Robert, Chen, Jonlin, Chen, Kai Yuan, Bu, Pengcheng, Wang, Lihua, Xu, Yitian, Munroe, Robert, Abratte, Christian, Miller, Andrew D., Gümüş, Zeynep H., Shuler, Michael, Nishimura, Nozomi, Edelmann, Winfried, Shen, Xiling, Lipkin, Steven M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532544/
https://ncbi.nlm.nih.gov/pubmed/26006007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3239
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