Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer

Current orthotopic xenograft models of human colorectal cancer (CRC) require surgery and do not robustly form metastases in the liver, the most common site clinically. CCR9 traffics lymphocytes to intestine and colorectum. We engineered use of the chemokine receptor CCR9 in CRC cell lines and patien...

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Publicat a:Nat Biotechnol
Autors principals: Chen, Huanhuan Joyce, Sun, Jian, Huang, Zhiliang, Hou, Harry, Arcilla, Myra, Rakhilin, Nikolai, Joe, Daniel J., Choi, Jiahn, Gadamsetty, Poornima, Milsom, Jeff, Nandakumar, Govind, Longman, Randy, Zhou, Xi Kathy, Edwards, Robert, Chen, Jonlin, Chen, Kai Yuan, Bu, Pengcheng, Wang, Lihua, Xu, Yitian, Munroe, Robert, Abratte, Christian, Miller, Andrew D., Gümüş, Zeynep H., Shuler, Michael, Nishimura, Nozomi, Edelmann, Winfried, Shen, Xiling, Lipkin, Steven M.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532544/
https://ncbi.nlm.nih.gov/pubmed/26006007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3239
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