FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis

Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. These toxic fatty acids can induce liver cell death and our recent results demonstrated that the biliary epithelium may be susceptible to lipotoxicity. Here, we explored the molecular mechanisms of ch...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Natarajan, Sathish Kumar, Stringham, Bailey A., Mohr, Ashley M., Wehrkamp, Cody J., Lu, Sizhao, Phillippi, Mary Anne, Harrison-Findik, Dee, Mott, Justin L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408604/
https://ncbi.nlm.nih.gov/pubmed/28250026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M071357
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