FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis

Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. These toxic fatty acids can induce liver cell death and our recent results demonstrated that the biliary epithelium may be susceptible to lipotoxicity. Here, we explored the molecular mechanisms of ch...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Natarajan, Sathish Kumar, Stringham, Bailey A., Mohr, Ashley M., Wehrkamp, Cody J., Lu, Sizhao, Phillippi, Mary Anne, Harrison-Findik, Dee, Mott, Justin L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408604/
https://ncbi.nlm.nih.gov/pubmed/28250026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M071357
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