Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates

Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine if immunization could induce antibodies to the V3-glycan bnAb binding site, we repetitively immuni...

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Publicado no:Cell Rep
Main Authors: Saunders, Kevin O., Nicely, Nathan I., Wiehe, Kevin J., Bonsignori, Mattia, Meyerhoff, R. Ryan, Parks, Robert, Walkowicz, William E., Aussedat, Baptiste, Wu, Nelson R., Cai, Fangping, Vohra, Yusuf, Park, Peter K., Eaton, Amanda, Go, Eden P., Sutherland, Laura L., Scearce, Richard M., Barouch, Dan H., Zhang, Ruijun, Von Holle, Tarra, Overman, R. Glenn, Anasti, Kara, Sanders, Rogier W., Moody, M. Anthony, Kepler, Thomas B., Korber, Bette, Desaire, Heather, Santra, Sampa, Letvin, Norman L., Nabel, Gary J., Montefiori, David C., Tomaras, Georgia D., Liao, Hua-Xin, Alam, S. Munir, Danishefsky, Samuel J., Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408352/
https://ncbi.nlm.nih.gov/pubmed/28249163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.003
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