Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody generation is lack of reverted unmutated ancestor (putative naive B cell rec...

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Main Authors: Ma, Ben-Jiang, Alam, S. Munir, Go, Eden P., Lu, Xiaozhi, Desaire, Heather, Tomaras, Georgia D., Bowman, Cindy, Sutherland, Laura L., Scearce, Richard M., Santra, Sampa, Letvin, Norman L., Kepler, Thomas B., Liao, Hua-Xin, Haynes, Barton F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164629/
https://ncbi.nlm.nih.gov/pubmed/21909262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002200
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