Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent AID activity, while improbable mutations occur where AID activity is infreque...

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Publicado en:Cell Host Microbe
Autores principales: Wiehe, Kevin, Bradley, Todd, Meyerhoff, R. Ryan, Hart, Connor, Williams, Wilton B., Easterhoff, David, Faison, William J., Kepler, Thomas B., Saunders, Kevin O., Alam, S. Munir, Bonsignori, Mattia, Haynes, Barton F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002614/
https://ncbi.nlm.nih.gov/pubmed/29861171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.04.018
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