Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Somatic mutations within antibody variable and framework regions (FWR) can alter thermostability and structural flexibility, but their impact on functional potency is unclear. Here we study thermostability and use molecular dynamics (MD) simulations to assess the role of FWR mutations during maturat...

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Udgivet i:Nat Commun
Main Authors: Henderson, Rory, Watts, Brian E., Ergin, Hieu N., Anasti, Kara, Parks, Robert, Xia, Shi-Mao, Trama, Ashley, Liao, Hua-Xin, Saunders, Kevin O., Bonsignori, Mattia, Wiehe, Kevin, Haynes, Barton F., Alam, S. Munir
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368608/
https://ncbi.nlm.nih.gov/pubmed/30737386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08415-7
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