Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, the ontogeny of distal MPER antibodies and the relationship of...

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Veröffentlicht in:Sci Immunol
Hauptverfasser: Williams, LaTonya D., Ofek, Gilad, Schätzle, Sebastian, McDaniel, Jonathan R., Lu, Xiaozhi, Nicely, Nathan I., Wu, Liming, Lougheed, Caleb S., Bradley, Todd, Louder, Mark K., McKee, Krisha, Bailer, Robert T., O’Dell, Sijy, Georgiev, Ivelin S., Seaman, Michael S., Parks, Robert J., Marshall, Dawn J., Anasti, Kara, Yang, Guang, Nie, Xiaoyan, Tumba, Nancy L., Wiehe, Kevin, Wagh, Kshitij, Korber, Bette, Kepler, Thomas B., Alam, S. Munir, Morris, Lynn, Kamanga, Gift, Cohen, Myron S., Bonsignori, Mattia, Xia, Shi-Mao, Montefiori, David C., Kelsoe, Garnett, Gao, Feng, Mascola, John R., Moody, M. Anthony, Saunders, Kevin O., Liao, Hua-Xin, Tomaras, Georgia D., Georgiou, George, Haynes, Barton F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905719/
https://ncbi.nlm.nih.gov/pubmed/28783671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aal2200
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