A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA

N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular enzyme, glutamate carboxypeptidase II (GCPII) in vivo. Inhib...

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Опубликовано в: :Mol Pain
Главные авторы: Nonaka, Takahiro, Yamada, Toshihiko, Ishimura, Tatsuhiro, Zuo, Daiying, Moffett, John R, Neale, Joseph H, Yamamoto, Tatsuo
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407666/
https://ncbi.nlm.nih.gov/pubmed/28326936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806917697008
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