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Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG)
RATIONALE: Metabotropic glutamate 2 and 3 receptors (mGluR2/3) are implicated in drug addiction as they limit excessive glutamate release during relapse. N-acetylaspartylglutamate (NAAG) is an endogenous mGluR2/3 agonist that is inactivated by the glutamate carboxypeptidase II (GCPII) enzyme. GCPII...
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| Vydáno v: | Psychopharmacology (Berl) |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5433920/ https://ncbi.nlm.nih.gov/pubmed/28251297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4568-y |
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