Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG)

RATIONALE: Metabotropic glutamate 2 and 3 receptors (mGluR2/3) are implicated in drug addiction as they limit excessive glutamate release during relapse. N-acetylaspartylglutamate (NAAG) is an endogenous mGluR2/3 agonist that is inactivated by the glutamate carboxypeptidase II (GCPII) enzyme. GCPII...

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Publicat a:Psychopharmacology (Berl)
Autors principals: Hicks, Callum, Gregg, Ryan A., Nayak, Sunil U., Cannella, Lee Anne, Schena, Giana J., Tallarida, Christopher S., Reitz, Allen B., Smith, Garry R., Rawls, Scott M.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433920/
https://ncbi.nlm.nih.gov/pubmed/28251297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4568-y
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