DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways

DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4. Both subunits are highly expressed in many diverse tumor cell lines and primary tumors, and this is correlated with poor p...

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Veröffentlicht in:Neoplasia
Hauptverfasser: Sasi, Nanda Kumar, Bhutkar, Arjun, Lanning, Nathan J., MacKeigan, Jeffrey P., Weinreich, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2017
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406526/
https://ncbi.nlm.nih.gov/pubmed/28448802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.03.001
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