DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

CDC7-DBF4 kinase (DDK) initiates DNA replication in eukaryotes by activating the replicative MCM helicase. DDK has diverse and apparently conflicting roles in the replication checkpoint response in various organisms, but the underlying mechanisms are far from settled. We show that human DDK promotes...

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Detaylı Bibliyografya
Yayımlandı:Neoplasia
Asıl Yazarlar: Sasi, Nanda Kumar, Coquel, Flavie, Lin, Yea-Lih, MacKeigan, Jeffrey P, Pasero, Philippe, Weinreich, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2018
Konular:
Original article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111017/
https://ncbi.nlm.nih.gov/pubmed/30157471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.08.001
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