Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does not increase mitochondrial function, which raises a question about the central role of Sirt1 in SRT1720 action. Moreover, it is believed that...

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Publicado en:EBioMedicine
Autores principales: Park, Sung-Jun, Ahmad, Faiyaz, Um, Jee-Hyun, Brown, Alexandra L., Xu, Xihui, Kang, Hyeog, Ke, Hengming, Feng, Xuesong, Ryall, James, Philp, Andrew, Schenk, Simon, Kim, Myung K., Sartorelli, Vittorio, Chung, Jay H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405165/
https://ncbi.nlm.nih.gov/pubmed/28396013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.03.019
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