Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis

AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including improved mitochondrial function in skeletal muscle and lowering of serum glucose levels in type-2 diabetes models. However, direct activation of AMP...

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Foilsithe in:PLoS One
Main Authors: Park, Sung-Jun, Ahmad, Faiyaz, Bahde, Robert J., Philp, Andrew, Kim, Jeonghan, Huang, Tianjiao, Kim, Myung K., Trenkle, William C., Chung, Jay H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8211267/
https://ncbi.nlm.nih.gov/pubmed/34138962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0253269
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