Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

The specific Sirt1 activator SRT1720 increases mitochondrial function in skeletal muscle, presumably by activating Sirt1. However, Sirt1 gain of function does not increase mitochondrial function, which raises a question about the central role of Sirt1 in SRT1720 action. Moreover, it is believed that...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Park, Sung-Jun, Ahmad, Faiyaz, Um, Jee-Hyun, Brown, Alexandra L., Xu, Xihui, Kang, Hyeog, Ke, Hengming, Feng, Xuesong, Ryall, James, Philp, Andrew, Schenk, Simon, Kim, Myung K., Sartorelli, Vittorio, Chung, Jay H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405165/
https://ncbi.nlm.nih.gov/pubmed/28396013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.03.019
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