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Peptide switch is essential for Sirt1 deacetylase activity
In mammals, the Sirtuins are composed of seven Sir2 orthologues (Sirt1-7) with a conserved deacetylase core that utilizes NAD(+) as a cofactor. Interestingly, the deacetylase core of Sirt1 by itself has no catalytic activity. We found within the C-terminal domain a 25 a.a. sequence that is essential...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3240942/ https://ncbi.nlm.nih.gov/pubmed/22017869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.07.038 |
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